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It is triggered by activation of inflammatory caspases, such as caspase-1, via inflammasomes (e.g., NLRP3), leading to the release of pro-inflammatory cytokines IL-1 and IL-18 and resulting in membrane rupture

doi: 10.1016/j.toxlet.2020.12.005

In PCOS patients, oligo/anovulation leads to reduced progesterone levels, which may result in inadequate inhibition of inflammation at the myometrium and maternal-fetal interface (155158)