For instance, researchers conducted a detailed proteomic analysis of Kaiyu Zhishen Decoction and identified its key active componentsprimarily flavonoids and phenolic acidsas major contributors to its antidepressant effects
This dual mechanism makes it one of the most thoroughly researched and clinically cited active ingredients in modern dermatology
PMID: 41313694 Toxicol Lett Discovery of non-steroidal aldo-keto reductase 1D1 inhibitors through automated screening and in vitro evaluation
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However, direct studies on their functional interactions are lacking
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