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The reason why Ozempic is effective for weight loss is because of semaglutide, a receptor agonist that mimics the GLP-1 hormone released in the gut in response to eating[3]

Clinical data suggests that a maintenance phase is often necessary to prevent the 2/3 weight regain that can occur if the medication is stopped abruptly without a transition plan

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Sastre, M., Klockgether, T

The 2006 Ionescu paper documented that pulsatile GH secretion persisted under continuous CJC-1295 stimulation, an unexpected finding that has shaped subsequent GH-axis research interpretation (PMID 17018654)