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Drucker and his team had a hint that the brain might be involved for two reasons: GLP-1 receptors are abundant in there, and the brain and the immune system communicate with all organs in the body

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Overall, while diarrhea and other digestive issues are common during the early stages of tirzepatide treatment, most people find that these side effects improve over time

GLP-1 receptor agonists slow gastric emptying and reduce appetite, which can lead to lower food and fluid intake if patients do not actively maintain hydration and nutrition

These molecular signals may likewise influence gutbrain communication in adulthood

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