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Venturoli C, Piga I, Curtarello M, et al

Manganese Manganese is the metal cofactor for mitochondrial SOD2

Prog Mol Biol Transl Sci 122:169192

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Sulforaphane, a compound found in cruciferous vegetables, was validated to activate the Nrf2/ARE pathway and inhibit NF-B pathway, thereby providing antioxidant and anti-inflammatory effects that are beneficial in DN models (Negi et al., 2011b)

Skin Repair Pathways MMP/TIMP, Collagen & Elastin (PMC, 2015) A focused review of GHK as a modulator of multiple skin regeneration pathways published in PMC confirmed that GHK-Cu stimulates both synthesis and breakdown of collagen and glycosaminoglycans, and modulates the activity of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs)