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Because of the cardiorenal benefits of RAASis, if these medications must be temporarily reduced or withheld due to hyperkalemia, a retrial of RAASi should be considered, potentially at a lower dose once hyperkalemia is resolved
One such process that demands large amounts of ATP is ion homeostasis maintained through the activity of ATP-dependent Na + -K + pumps 58
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2020;18(2):337e34619
Figure from Rossing et al NDT 2023 Primary Outcome This was a composite of time of first occurrence of: Onset of kidney failure (persistent eGFR 28 days or initiation of long-term KRT, kidney transplantation) Persistent 50% reduction in eGFR from baseline Death from kidney or CV causes Secondary Outcomes Confirmatory secondary outcomes were analyzed hierarchically
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