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On November 5, 2025, CMS finalized the adoption of two new RPM CPT codes, 99445 and 99470, that directly address the flexibility gaps providers and professional organizations like the American Medical Association have been advocating for since RPM's formal introduction in 2019

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(2022) also found that proteins with flexible, random coil structures were more effective in rearranging at the interface during emulsions and foam formation than highly ordered proteins, which do not unfold as easily to interact with the surrounding medium