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The solvent was evaporated in vacuo to give a crude mixture that was further purified by HPLC (water and acetonitrile, both supplemented with 0.1% trifluoroacetic acid) on a Cosmosil C18 AR-II column (5.0 m, 10 250 mm

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(Of these four hormones, only T3 and T4 are biologically active, with T3 being the main biologically active form.) Other organs also play a role in thyroid hormone production

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