Celecoxib, a highly selective COX-2 inhibitor, has been shown to suppress neuronal hyperexcitability and reduce seizure frequency in pilocarpine- and kainate-induced epilepsy models, suggesting its potential therapeutic utility in epilepsy management (Lim et al., 2019) In addition, MCC950, an NLRP3 inflammasome inhibitor, has demonstrated significant neuroprotective effects in animal studies by reducing neuronal damage after status epilepticus (SE) and alleviating depressive-like behaviors, representing a novel avenue for precision anti-inflammatory therapy (Hong et al., 2024)
5-Amino-1MQ formally 5-amino-1-methylquinolinium iodide is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT)
TMS delivers a precise magnetic pulse that disrupts this wave, effectively hitting the "Reset Button" on the brain's electrical activity
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At the same time caution is warranted: the 2025 study also works with cell lines, not with humans
Glutathione is made up of three amino acids (glutamine, cysteine, and glycine) and is found in every cell of the body, where it plays a key role in protecting against oxidative stress, supporting detoxification, and maintaining overall cellular health
