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The SURMOUNT-4 trial (Aronne 2023, JAMA) showed that adults who stopped tirzepatide after 36 weeks regained an average of 14.0% of body weight over the next 52 weeks, while those who continued tirzepatide lost an additional 5.5% a 19.4% between-group difference

273 GLP-1RAs and RA The role of GLP-1RA was also investigated in RA, which is characterized by chronic inflammation of the synovium and joint destruction