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Data from the European LEOSS registry as well as other data show an additive effect of obesity, diabetes, and hypertension on the risk of mortality, which is higher in young and middle-aged patients (1855 years)

(Lancet, 2023), and Sanyal et al

Unfortunately, GLP-1 can decrease with age and lifestyle

Mechanism of Action of GLP-1RAs in Type 2 Diabetes These effects have positioned GLP-1RAs as a cornerstone in the management of type 2 diabetes, particularly in individuals with obesity

This is partly because GLP-1s slow the digestive tract, reducing hydration

Comparative effectiveness of sodiumglucose cotransporter 2 inhibitors vs sulfonylureas in patients with type 2 diabetes