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For patients with inadequate response, tirzepatide (a GLP-1/GIP receptor agonist) offers dual-pathway activation and may produce superior weight loss

Tens of thousands of people have swapped their supplement routine for patches and they're not going back

In December 2014, they published a paper in Nature Medicine, showing that the triple agonists weight loss effects in mice exceeded those of the dual agonists

The study results will be submitted for publication in a peer-reviewed journal, with findings expected in 2026

West says long-term data are needed to confirm these projections, however

It works through several pathways, including activation of AMP-activated protein kinase (AMPK), which improves insulin sensitivity and lowers blood glucose levels