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This is why GLP-1 weight management should be approached as part of a broader long-term treatment plan rather than a short-term fix

FIGURE 3 Mammalian CBS is an unusual PLP enzyme that contains a heme cofactor and S -adenosyl-L-methionine (SAM)

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They may be considered in patients with high previous HbA1c levels (9%) or in those whose basal insulin dose is already optimized and prandial control is required.21,22Table 5 shows the characteristics of premixed insulins as compared to basal insulin alone and to the basal/bolus regimen