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The mTORC1 activity phosphorylates multiple substrates, with S6K1 and the initiation factor 4E binding proteins (4E-BPs) being the best characterized [106-108]

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This can build up over time, but multiple sessions may have to be done

Referral to an endocrinologist is recommended for patients who are pregnant or planning pregnancy, pediatric patients, those with nodules or goiter, discordant laboratory results, persistent symptoms despite normal TSH, or suspected myxedema coma (requiring urgent care)

Rest the weekends to allow the peptide and body to reset