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PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways

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However, ABHD11 inhibition had mixed effects on KDM activity, and only histone 3 lysine 4 trimethylation (H3K4me3) was increased, indicating that the effect of ABHD11 inhibition on 2-OGDDs is not uniform across this enzyme group (Extended Data Fig