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To further characterize and validate our findings from the primary analysis, additional subgroup comparisons were conducted across three distinct matched cohort analyses: (1) GLP-1 RAs versus insulin monotherapy, (2) GLP-1 RAs versus metformin monotherapy, and (3) GLP-1 RAs versus SGLT2 inhibitor monotherapy

This adipokine is predominantly produced by white adipose tissue, but low levels of expression are also detected in the hypothalamus

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