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If upregulation of citrate synthase occurred due to excess PPA in vivo and then PPA was removed in vitro , the high activity of citrate synthase in vitro would overproduce citrate and enhance the proximal portion of the TCAC, which preferentially produces NADH, the electron carrier metabolized by complex I

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Aging Cell 22 , e13965 (2023)

However, she wasn't on it very long before she "got into the bad bingeing" and took herself off the medication