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In patients suffering from auto-immune diseases, malignant myelo-proliferative syndromes, multiple myeloma, acute and chronic lymphatic leukaemia, solid tumour, sepsis or trauma, the concentration of circulating proteasome has been found to be elevated, to correlate with the disease state, and may have prognostic significance

doi:10.1210/en.2013-1765

H., & Kim, B

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Unlike NSAIDs, acetaminophen works primarily in the brain and spinal cord rather than throughout the body, which explains why it's effective for pain and fever but doesn't reduce inflammation like NSAIDs do (Li et al., 2013

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