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(2013) The cystine/glutamate antiporter system x c in health and disease: from molecular mechanisms to novel therapeutic opportunities, Antioxid

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3.3 Molecular mechanisms of supraspinatus atrophy Supraspinatus atrophy in chronic rotator cuff tears (RCTs) results from disrupted protein homeostasis, neuromuscular impairment, inflammation, mitochondrial dysfunction, oxidative stress, and circadian rhythm dysregulation (Wan et al., 2022)

Kappos et al., 2018

It has been shown that rhein inhibits CYP2C9, CYP1A2, CYP2E1, CYP2D6 and CYP3A enzymes in rat liver (Tang et al., 2009)

The body can finally downregulate its stress response and enter parasympathetic (rest-and-digest) mode instead of remaining in sympathetic (fight-or-flight) activation