Many thanks to Professors Peter Jones and Steve ORahilly and Dr Husseini Manji for valuable input and discussions and Dr Vivian Lee for help with gene ontology analysis
Notably, britanin (Bri), a sesquiterpene lactone extracted from Inula japonica, also reduces AMPK phosphorylation, downregulates SREBP1c expression, and alleviates hepatic oxidative stress and apoptosis by decreasing Caspase3 expression and the Bax/Bcl2 ratio, thereby mitigating NAFLD (Dou et al., 2024)
10.1016/j.envres.2023.117163 373 YangN.WangY.ZhangQ.ChenL.ZhaoY
Even trace quantities of certain leachable compounds can be clinically relevant
In contrast to postsynaptic adhesion molecules, very few species have been found in the current identification of presynaptic adhesion molecules [47]
Mercury is stored in the brain at higher levels than in the rest of the body