GLP-1 medications reduce progression from prediabetes to diabetes by 72% compared to control groups 6
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For others, especially those with a history of restrictive eating, binge eating, body image distress, or disordered eating patterns, these medications require careful screening and medical supervision
They stimulate glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release from alpha cells, slow gastric emptying, and promote satiety through central nervous system effects
Graphical Abstract Access this article Similar content being viewed by others Abbreviations COX1: Cylco-oxygenase-1 COX2: Cylco-oxygenase-2 DT: Diphtheria toxin DTR: Diphtheria toxin receptor FBG: Fasting blood glucose GLP-1: Glucagon-like peptide-1 GSIS: Glucose-stimulated insulin secretion HFD: High-fat diet IAM: Islet-associated macrophage LPS: Lipopolysaccharide LPM: Large peritoneal macrophage PGE2: Prostaglandin E2 PM: Peritoneal macrophage qRT-PCR: Quantitative real-time PCR SPM: Small peritoneal macrophage VS: Valeryl salicylate WT: Wild-type References Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes
Early warnings suggested a link between GLP1 therapy and pancreatitis
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