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Retrieved March 4, 2017

In most cases, you'll receive a B12 shot in an outpatient setting

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3 to 7 days Clearer thinking, steadier mood, more stamina 2 to 4 weeks Steadier energy and more consistent day-to-day benefits 2 to 3 months+ Longer-term support for nerve function and steady Why a Shot Works Faster Than Oral Supplements When you swallow a B12 pill, it has to travel through your stomach and small intestine and rely on a protein called intrinsic factor to be absorbed