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Chadebech P, Michel M, Janvier D, Yamada K, Copie-Bergman C, Bodivit G, et al
The corresponding cystein and glutamate residues have been described as key catalytic residues of the aldehyde dehydrogenase family (Shortall et al., 2021)
Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis
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When this process is inhibited it can result in accumulated proteins, toxins, and inflammatory metabolic byproducts in the brain that may contribute to dementia
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