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Vitamin B6 is a cofactor and can also be depleted by increased CBS activity

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Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis

Olasupo Odunsi, MD, Medical Director Reviewed July 5, 2026 If you're constantly tired and your metabolism feels stuck, low B12 could be part of the problem

10.1200/jco.2015.33.15_suppl.2512 66 HartleyJ

This can lead to an imbalance in the gut flora, and can cause inflammation and other problems