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Metabolic Roles L-arginine Semi-essential amino acid Direct precursor to nitric oxide Involved in protein synthesis and hormone secretion functions L-citrulline Non-essential amino acid Converted to L-arginine in the kidneys Involved in the urea cycle Absorption and Bioavailability L-citrulline has been shown to have an advantage over L-arginine in terms of absorption and bioavailability: L-citrulline is noted as being efficiently absorbed by the intestines

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X

Diabetologia (2012) 55(3):81224

10.1016/j.freeradbiomed.2015.04.036 37 DjouadiF.AubeyF.SchlemmerD.BastinJ

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The Compound That Healed Everything His team's first paper on it lands in 1992