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There is a shifting trend in the risk factors associated with heart failure in epidemiological studies from classic smoking and hypertension as risk factors for ischemic heart disease and heart failure with reduced ejection fraction, to morbid obesity, diabetes mellitus, and metabolic syndrome in the aging population as risk factors for heart failure with preserved ejection failure [5]

Some studies have shown that increased abdominal visceral fat mass is the best predictor of GH secretion attenuation in humans, and that dietary restriction leading to substantial weight loss restores GH secretion

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The hormonal and physiological landscape during pregnancy and lactation is incredibly complex and delicate