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Modifier -25: Significant, separately identifiable E/M service When a clinician performs an evaluation and management (E/M) service on the same date as a wound repair, Modifier -25 must be appended to the E/M code to demonstrate that the visit was a significant, separately identifiable service beyond the repair itself

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A 2025 Nature Communications paper mapped the binding to the disordered transactivation domain of p53, adding structural detail to how FOXO4-DRI engages its target