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Oral administration faces hepatic first-pass metabolism, reducing bioavailability to approximately 4050% of subcutaneous routes, but offers convenience for longer-term studies where daily injections create compliance challenges

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[DOI] [PubMed] [Google Scholar] 10.Finkel Y., Eklf A.C., Granquist L., Soares-da-Silva P., Bertorello A.M

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