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-MSH regulates pigmentation, energy homeostasis, immune regulation, and inflammation

However, AMPKs effects are context-dependent: under nutrient-replete conditions, AMPK-deficient T cells maintain normal responses, but during glucose restriction or metabolic stress, their adaptability is severely impaired (84)

Sakakibara Y, Sato S, Kawashima Y, Someya Y, Shirato K, Tachiyashiki K, et al

doi: 10.1016/j.biopsych.2016.12.031 221 DinanTGCryanJF

Daeshiho-tang attenuates inflammatory response and oxidative stress in LPS-stimulated macrophages by regulating TLR4/MyD88, NF-B, MAPK, and Nrf2/HO-1 pathways

Chronic cortisol dysregulation promotes a state of auditory cortex hypervigilance, effectively turning up the gain on internal signals that would otherwise be filtered out