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It is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma (MTC) or with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

FASEB J 23:5867 Wang Z, Thurmond DC (2009) Mechanisms of biphasic insulin-granule exocytosisroles of the cytoskeleton, small GTPases and SNARE proteins

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In: Azuma J, Schaffer SW, Ito T, editors

The descent to the bottom of the canyon (4,160 m / 13,648 ft) is one of the deepest in the world