Tight junction proteins are the main functional proteins of the intestinal barrier, which will enlarge the intercellular space, increase intestinal mucosal permeability to increase translocation of bacteria such as Lipopolysaccharide (LPS) to cause inflammatory response (Horowitz et al., 2023)
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In addition to acting on opioid receptors, opioid peptides have also been shown to interact with toll-like receptors (TLR), particularly TLR4 (Eidson and Murphy 2013
Rodent doses may not translate directly to human physiology