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Each type of fermentable fiber produces different ratios of butyrate, propionate, and acetateall of which activate L-cells through slightly different mechanisms

The most widely cited early dataset is a Phase 2 trial in adults with obesity/overweight without diabetes, published in 2023

Subjects with mutations enriched for the leucine repeat kinase 2 (LRRK2) gene had higher quantities of 8-OHdG and 8-ISO in their cerebral fluid (Loeffler et al., 2017)

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Epilepsy and respiratory chain defects in children with mitochondrial encephalopathies