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Mechanistically, PRPS1 serine 83 (S83) and threonine 166 (T166) O -GlcNAcylation mediated by OGT leads to PRPS1 hexamer formation and reduction of feedback inhibition of PRPS1 activity, thereby promoting PRPS1 activation, nucleotide synthesis and NAD production

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Postmortem Human Brain Study Human brain samples Human brain samples from both normal subjects and patients with PTSD underwent neuropathological examination