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Retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, has shown even more dramatic weight loss in clinical trials, with some participants losing over 25% of their body weight

In young male mice (3 weeks of age), nine weeks of CR significantly suppressed both trabecular and cortical bone accrual in the femur

doi: 10.1186/s10020-024-00817-8

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The other thing, and this is not editorial, this is a real observation, pharmaceutical companies are very interested in the other uses of already approved drugs