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doi:10.3803/enm.2019.34.3.247

Glucagon-like peptide-1: a potent regulator of food intake in humans

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For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity

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While mild to moderate nausea is expected with GLP-1 therapy, certain symptoms warrant prompt medical evaluation