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47,48 GLP-1 agonists impact the dopamine signaling in the mesolimbic pathway and regulate the reward-motivated behavior in alcohol consumption, thus showing potential as a pharmacotherapeutic intervention

Furthermore, the dissociation rate with the receptor is slow, and the high affinity and slow dissociation with the receptor prolongs the time of pharmacological effect (58, 60)

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In brown and beige adipose tissue, glucagon signaling increases uncoupling protein 1 (UCP1) expression and thermogenesis, directly raising resting energy expenditure