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These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects

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Many studies have questioned if an increase in maternal folate during pregnancy, with the main aim of reducing neural defects, could somehow be related to an increased risk of ASD in children because the timing of neural tube closure, and therefore the use of folic acid corresponds with embryogenesis