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By activating caspase-3 and modulating the balance between BAX and BCL-2 expression, BV promotes apoptosis and inhibits the proliferation of synovial cells, thereby alleviating the pathological effects of RA on joint tissues

The anti-arthritic activity of BA is due to the inhibition of NF-B, COX-2, LOX-5 (Anilkumar 2010)

The arithmetic mean cost of $1,241 falls within the cost band for APC 1514 (New TechnologyLevel 14 ($1201-$1300))

Any supplier unwilling or unable to provide current COAs should be avoided entirely

to 95% Curcuminoids))

Kaur R., Naaz F., Sharma S., et al., Screening of a Library of 4Aryl/Heteroaryl4HFused Pyrans for Xanthine Oxidase Inhibition: Synthesis, Biological Evaluation and Docking Studies, Medicinal Chemistry Research 24 (2015): 33343349, 10.1007/s00044-015-1382-0