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With a growing number of patients using these medications for diabetes or to meet certain optimization goals before undergoing hip and knee reconstructive surgery, our aim was to establish evidence-based guidelines on when to discontinue these to enhance patient safety and surgical success." The study, "Optimal Timing for Cessation of GLP-1 Agonist Before Elective Total Hip and Knee Arthroplasty," obtained data from the TriNetX Research Network, a multi-institutional national aggregated database, to identify patients who underwent TKA or THA from January 1, 2018 to January 1, 2023

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One canonical way for -KG to regulate gene transcription is to act as an epigenetic cofactor for Fe 2+ -dependent and 2-oxoglutarate-dependent dioxygenases (2OGDDs), including TET DNA demethylases and Jumonji C domain-containing histone demethylases (JMJD3 and UTX) 16,42,43