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Description

The proposed net effect in experimental systems is a shift in energy substrate utilisation without the hyperglycaemic liability that pure glucagon agonism would carry alone

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These are three chemically related but distinct receptors that have their own distinct biology, says Richard DiMarchi, professor of chemistry and chair in biomolecular sciences at Indiana University

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Nonetheless, residual effects on gastric emptying could still produce significant gastrointestinal adverse effects in patients treated with long-acting GLP-RAs (167)

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