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A 2025 retrospective cohort study of 210 T2DM patients on oral semaglutide for 18 months found no significant association between rs6923761 or rs761387 genotypes and changes in HbA1c or BMI in that relatively well-controlled population (Candido et al., 2025) suggesting that receptor-level genotype effects may be detectable primarily in subpopulations with higher pharmacological demand or larger baseline disease severity, rather than as universal predictors
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What is Semaglutide, and what is it used for
This can manifest as irregular menstrual cycles, anovulation, difficulty getting pregnant, or miscarrying
Zhang G, Wei H, Zhao A, et al
What Youre Giving Up (and What Youre Not) Lets be direct about this
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