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By stimulating the testes directly, it helps maintain their function during the transition period while the pituitary slowly resumes normal LH production

Key findings from the new studies: ARTIOS trial: Patients who switched to Kesimpta after experiencing relapses or MRI activity on other oral treatments showed fewer relapses, suppressed MRI activity, and over 90% achieved no evidence of disease activity (NEDA-3)

J Clin Endocrinol Metab (2001) 86(8):384552.10.1210/jcem.86.8.7731 203 GoodyerCGZogopoulosGSchwartzbauerGZhengHHendyGNMenonRK

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Molecular functions associated with these downregulated proteins included endopeptidase inhibitor activity, enzyme binding, and chaperone binding

The most likely explanation is that semaglutide side effects, particularly dehydration from GI symptoms , indirectly increase clot risk in some users, while the drug direct anti-platelet and anti-inflammatory effects provide protection in others