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*7 Life SCI.2010 Jun 5;86(23-24):894-8.doi:10.1016/j.lfjs.2010.04.009.Epub 2010 Apr 25.-Iwaoka Y., Hashimoto R., Koizumi H., Yu J., Okabe T

The murmur sound is caused by the turbulent flow of blood jetting backwards through the damaged leaflets of the mitral valve from the left ventricle, into the left atrium

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Accordingly, PCSK9 downregulation exerts anti-inflammatory effects by inhibiting the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), potentially increasing anti-inflammatory cytokines, and upregulating immunosuppressive T regulatory (Treg) cells in models of atherosclerosis (Liu and Frostegrd, 2018