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Accessed on March 21, 2025, at A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight With Weight-Related Comorbidities

Pearce L, Galan-Arriola C, Bell RM, Carr RD, Cunningham J, Davidson SM, Ghosh AK, Giesz S, Golforoush P, Gourine AV, Hermann DM, Heusch G, Ibanez B, Kalkhoran SB, Lecour S, Lukhna K, Ntsekhe M, Sack MN, Unwin RJ, Vilahur G, Walker JM, Yellon DM (2024) Inter-organ communication: pathways and targets to cardioprotection and neuro-protection

The global CVD burden is expected to see a 3.6% year-on-year increase from 2025 to 2050 [5], thus emphasizing the need for effective strategies in cardiometabolic prevention within the global health conundrum [6,7,8,9]