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Protocol: Started at 0.5mg weekly (weeks 1-2), increased to 1mg weekly (weeks 3+)

Supplementary Information accompanies the paper on the Neuropsychopharmacology website ( Supplementary information Rights and permissions About this article Cite this article Lavoie, S., Murray, M., Deppen, P

31.6% of cagrilintide participants achieved greater than 15% weight loss, compared to just 4.7% on placebo

In a rat model of col-induced arthritis, a single intra-articular injection of prednisolone-loaded liposomes significantly reduced paw swelling and inflammatory cytokines within several weeks, outperforming systemic administration [377]

We clamped arterial glucose using a variable rate of glucose (plus trace [3- 3 H]-glucose) infusion, this was adjusted using blood glucose measurements collected at 10 min intervals