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it's about preserving the potential for discovery
NNMT and Cancer Elevated NNMT expression has been observed in several forms of cancer, including gastric, pancreatic, renal cell carcinoma, and bladder cancers
[6] Proposed mechanisms for cardiovascular benefits of incretin-based therapies include: Vascular effects : Improved endothelial function and reduced arterial stiffness Anti-inflammatory actions : Decreased systemic inflammation and oxidative stress Metabolic improvements : Enhanced insulin sensitivity and reduced hepatic glucose production Hemodynamic changes : Blood pressure reduction, though with modest increases in heart rate Renal protection : Reduced albuminuria and preservation of kidney function The cardiovascular benefits appear partially independent of weight loss itself, suggesting potential cardioprotective properties of incretin pathway activation
Special Precautions Do not use for type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis
Why advancing is key The goal of oral drug technologies is to beat GLP1s' fragility in the digestive tract, potentially replacing injections for many patients by improving convenience and adherence
For companies across the pharmaceutical value chain, the opportunity is not just to follow the shift from injectables to oral delivery
