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Medications can cause either exogenous or endogenous pigmentations

When someone loses 20% or more of their body weight in under a year, the skin and underlying connective tissue cannot remodel fast enough to keep up with the shrinking fat deposits beneath them

Systemic Effects : Remarkably, BPC 157 can be effective even when injected away from the injury site, suggesting it can work through systemic action

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doi: 10.1016/j.metabol.2020.154388 [DOI] [PubMed] [Google Scholar] 4