Again, this was a small pilot study without a control group
*Correspondence: Consolato Sergi [email protected]/0000-0002-2779-7879 This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology Fan Shen orcid.org/0000-0001-7432-8891 Song-Mei Liu orcid.org/0000-0001-9276-6078 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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eClinicalMedicine 37:100895
Theoretical Risks with Chronic Use Some concerns raised by clinicians and researchers include: Unregulated angiogenesis: Overstimulation of blood vessel growth could hypothetically support tumor progression in cancer-prone individuals Unknown hormonal crosstalk: While BPC-157 is non-hormonal, it interacts with systems (e.g., nitric oxide, dopamine) that may influence downstream signaling Immune tolerance or desensitization: Chronic exposure to any peptide could alter immune recognition or receptor sensitivity over time These concerns are theoretical , but they highlight why BPC-157 should not be used indefinitely or in uncontrolled cycles
They can also evaluate whether any weight retention relates to medical conditions requiring specific treatment
