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In summary, the harsh metabolic landscape of the TME, characterized by nutrient competition, accumulation of immunosuppressive metabolites, and dysregulated lipid and amino acid metabolism, severely impairs the function and fate of infiltrating immune cells, ultimately promoting tumor immune evasion and progression

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It has been reported that diabetic patients that are obese will experience more severe hypohidrosis of the feet (63a)

This was mediated by the activation of the S100B/RAGE signaling pathway [110]

Deviating from standard titration schedules can increase adverse effects and reduce tolerability