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The COR-I trial, involving 1,742 participants over 56 weeks, demonstrated 6.1% average weight loss with Contrave versus 1.3% with placebo (Greenway et al., Obesity, 2010)

As a result, users experience accelerated weight loss, but with the potential for serious side effects, including gastrointestinal distress and muscle weakening

Monitoring: when should you re-check thyroid bloods